Discontinued

Disease: Solid Tumours

Disease info:

An abnormal mass of tissue that usually does not contain cysts or liquid areas. Solid tumours may be benign (not cancer), or malignant (cancer). Different types of solid tumours are named for the type of cells that form them. Examples of solid tumours are sarcomas, carcinomas, and lymphomas. LeukAemias (cancers of the blood) generally do not form solid tumours.

Frequency:
Based on projections, cancer deaths will continue to rise with an estimated 9 million people dying from cancer in 2015, and 11.4 million dying in 2030.
Official title:
EDIT-201
Who:
Locations:
Study start:
Enrollment:
Gene editing method:
CRISPR-Cas12α
Gene:
TGFβR2 Transforming Growth Factor Beta Receptor 2 , CISH Cytokine-Inducible SH2-Containing Protein
Delivery method:
Electroporation - Ex-vivo
IND Enabling Pre-clinical
Phase I Safety
Phase II Safety and Dosing
Phase III Safety and Efficacy

Status:

Description

EDIT-201: Allogeneic Healthy Donor NK (HDNK) Cell Medicine that uses CRISPR-Cas12a gene editing to enhance NK cell effector function through double knockout of CISH and TGFBR2 genes

Last updated: Sep. 7, 2021
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