Scientist / Scientist II / Sr. Scientist, Platform Technology (Protein Sciences)


Spotlight Therapeutics

Job type

Full time


We are looking for a protein biochemist/molecular engineer to join our Platform Technology group. This individual will work closely with Spotlight’s Scientists to engineer CRISPR ribonucleoprotein (RNP) complexes for direct/cell-targeted in vivo delivery, for therapeutic genome editing. The successful candidate will have extensive, hands-on experience with rational engineering and/or screening-based approaches to optimize protein activity, a passion for working on new and highly differentiated early-stage prototypes, and a clear record of being able to move projects forward.

Responsibilities include but are not limited to, the following:

  • Lead protein engineering efforts to optimize CRISPR nuclease cell-targeting, cellular internalization and trafficking
  • Perform in-vitro, ex vivo, and in-vivo characterization of cell-targeted CRISPR nuclease activity, quantify DNA repair outcomes from gene editing experiments
  • Coordinate efforts with internal and external stakeholders
  • Communicate results clearly and concisely, keep accurate record of experiments and results
  • Keep up to date with scientific literature in relevant fields

Candidate must possess:

  • Doctoral degree (PhD or equivalent) in a related scientific discipline, experience in biopharma industry preferred

Desired skills and pluses:

  • Experience inspiring and leading a small team
  • Antibody and/or CRISPR-Cas engineering, expression, purification, and characterization
  • Experience in a variety of chromatography techniques including: affinity, IEX, SEC and familiarity with writing methods for the ӒKTA FPLC
  • Experience characterizing large proteins and complexes using: HPLC, DLS, MS, etc.
  • Expertise with scar-less molecular cloning techniques
  • Experience with NGS library preparation
  • Experience or a high level of familiarity with genome editing
  • Organized, responsible, team-player, good communicator, self-starter

Interested candidates can send their CV and cover letter to with “[Scientist-Platform]” in the subject line of the email.

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