| Tuneable, Biodegradable, Lipid-Like Nanoparticles for In Vivo mRNA DeliveryIn recent years, a number of non-viral delivery vehicles have emerged within the gene editing field, including biocompatible carriers for mRNA such as lipid and polymer-based nanoparticles. Of these, lipid nanoparticles have been extensively developed towards improved efficiency and low toxicity, but their biodegradability remains a concern. To address this issue, Yizhou Dong and his group at Ohio State University have recently developed a series of biodegradable and tuneable lipid-like nanoparticles that efficiently deliver large therapeutically relevant mRNA molecules in vivo. We interviewed Yizhou Dong to learn more about the work, and share the story in our latest piece. | |
