CRISPR Medicine News, 22 September 2020 | Tuneable and Biodegradable Nanoparticles for In Vivo mRNA Delivery - CRISPR Medicine

Tuneable, Biodegradable, Lipid-Like Nanoparticles for In Vivo mRNA Delivery

In recent years, a number of non-viral delivery vehicles have emerged within the gene editing field, including biocompatible carriers for mRNA such as lipid and polymer-based nanoparticles. Of these, lipid nanoparticles have been extensively developed towards improved efficiency and low toxicity, but their biodegradability remains a concern.

To address this issue, Yizhou Dong and his group at Ohio State University have recently developed a series of biodegradable and tuneable lipid-like nanoparticles that efficiently deliver large therapeutically relevant mRNA molecules in vivo. We interviewed Yizhou Dong to learn more about the work, and share the story in our latest piece.

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