This week’s update looks at a Phase 1/2 study for ALLO-501A, a TALEN-edited CAR T-cell therapy for...

Editing a single nucleotide in the largest human gene is sufficient to restore dystrophin production...

Some of the best stuff we picked up around the internet

This week’s update looks at a CRISPR-edited CAR T-cell therapy in clinical development for the...

β-Thalassemia is caused in part by a mutated β-globin gene, so researchers developed a way to...

Some of the best stuff we picked up around the internet

This week’s update looks at a combined vaccine/CRISPR-edited T cell trial for prostate cancer, and a...

Researchers at University of Freiburg in Germany have developed the first assay to identify and...

Some of the best stuff we picked up around the internet

In this brief roundup, we look at what's going on in the CRISPR Medicine field for Leber congenital...

DNA repair by a hitherto overlooked mechanism - non-homologous blunt-end joining – might lead to a...

Some of the best stuff we picked up around the internet

Erik Sontheimer, Professor and Vice Chair at the RNA Therapeutics Institute and at the University of...

In recent years, researchers have turned to gene editing to address the limitations of CAR T...

Professor Jin-Soo Kim, from the Center for Genome Engineering at the Republic of Korea’s Institute...

Some of the best stuff we picked up around the internet

This week’s clinical update looks at 3 clinical trials for the treatment of sickle cell disease...

Almost complete efficiency of gene knock-in is achieved with a new CRISPR-based system developed by...

Some of the best stuff we picked up around the internet

This week’s clinical update looks at 3 clinical trials for CRISPR-edited CAR T therapies for the...

Pharmaceutical and biological research as well as biologics manufacturing rely on genetically...

A novel, highly potent lipid nanoparticle (LNP) CRISPR-Cas9 delivery system targets the liver more...

Some of the best stuff we picked up around the internet

This week’s clinical update looks at two clinical trials for beta thalassemia using...

The mechanism our immune system uses to fend off viruses also attacks AAV vectors. Adding telomeric...

Some of the best stuff we picked up around the internet

This week’s update looks at DA01, the first gene-edited cell therapy for Parkinson’s disease (PD) to...

The group of Mario Amendola has used CRISPR-based editing of haematopoietic stem cells to generate a...

Some of the best stuff we picked up around the internet

Locus Biosciences announced on Wednesday that it successfully completed the world's first clinical...

Andre Watson, the founder of the gene delivery platform company Ligandal, quickly pivoted his...

Some of the best stuff we picked up around the internet

CRISPR-Cas is seen as the holy grail in medicine for rare and incurable genetic diseases. In this...

DECODR's algorithm can quickly — and cheaply — make sense of Sanger sequencing data at a very...

Some of the best stuff we picked up around the internet

This week’s clinical update looks at a trial to evaluate a combined CRISPR-Cas12a/PCR detection...

A constant battle between prokaryotes and phages has shaped how CRISPR is controlled and regulated....

Some of the best stuff we picked up around the internet

This week’s update looks at a Phase 1 clinical trial for a new meganuclease-edited CAR T-cell...

At the beginning of a genome editing revolution one of the great challenges is the need for a common...

Some of the best stuff we picked up around the internet

A new generation of therapies based on CRISPR-Cas and other gene-editing technologies brings hope to...

Researchers can manipulate genomes at the single-base level, but they still struggle to predict and...

Some of the best stuff we picked up around the internet

This week’s gene-editing clinical trial update looks at a universal dual specificity CD19 and...

With a new IND in hand, Graphite Bio plans to begin clinical trials for a CRISPR treatment that will...

Some of the best stuff we picked up around the internet

This week’s IND update looks at two distinct gene-editing strategies for sickle cell disease, both...

Leber congenital amaurosis is a group of rare inherited retinal diseases that lead to blindness over...

Some of the best stuff we picked up around the internet

The CRISPR gene-editing therapy more than doubled the lifespan in a mouse model by tackling the root...

Kevin Davies, author and Executive Editor of The CRISPR Journal, says that CRISPR is as close as...

In this disease-oriented roundup, we take a look at clinical-stage gene-editing approaches to sickle...

This year CRISPR broke new ground in medicine. We saw the first CRISPR gene editing directly in the...

Update on Allogene Therapeutics off-the-shelf CAR-T cancer therapies. This week’s gene-editing...

A disease model using patients’ own cells demonstrates that prime editing can be used for functional...

Some of the best stuff we picked up around the internet

In this week’s clinical update, we look at three clinical-stage CRISPR-engineered cell therapies...

Lack of efficient delivery vehicles has so far hampered CRISPR-Cas9 editing in non-liver tumours....

Some of the best stuff we picked up around the internet

Just 8 years after the development of CRISPR-Cas technology, Vertex Pharmaceuticals and CRISPR...

The new electric field-driven 'lab-on-a-chip' use CRISPR-Cas12 to rapidly detect the SARS-CoV-2 in...

Some of the best stuff we picked up around the internet

Last week, we bought you our first IND update for a selection of gene-editing therapies currently...

CRISPR is set to change the face of medicine, and is already contributing to a huge number of...

Some of the best stuff we picked up around the internet

Clinical trials to assess the safety and medical benefit of CRISPR therapies are complex. This is...

Some of the best stuff we picked up around the internet

Researchers have shown that CRISPR-Cas9 knockout of CISH, a negative regulator of T cell immunity,...

We have added 4 new CRISPR-Cas trials to our overview of current clinical trials involving gene...

Some of the best stuff we picked up around the internet

We have added 6 new cancer trials to our overview of current clinical trials involving gene editing.

A CRISPR-Cas9 treatment reactivated a crucial gene in mice and human neurons — hinting at a possible...

Some of the best stuff we picked up around the internet

Professor Waseem Qasim, of University College London and Great Ormond Street Institute of Child...

Some of the best stuff we picked up around the internet

We have added three clinical trials to our comprehensive database of the current CRISPR-based trials...

Researchers found a highly efficient repressor for CRISPRi experiments, ZIM3, which can repress gene...

Some of the best stuff we picked up around the internet

Virtual event featured talk from recent Nobel Prize recipient Jennifer Doudna, as well as in-depth...

California-based gene-editing company Scribe Therapeutics recently unveiled its plans to develop the...

Some of the best stuff we picked up around the internet

With the Nobel Prize in Chemistry being awarded to the founding mothers of CRISPR - Emmanuelle...

Some of the best stuff we picked up around the internet

The Royal Swedish Academy of Sciences today awarded the Nobel Prize in Chemistry to Drs. Emmanuelle...

Our clinical trials database is a comprehensive collection of the current CRISPR-based trials for...

Some of the best stuff we picked up around the internet

Off-target editing is a significant problem with CRISPR and something that scientists really want to...

Some of the best stuff we picked up around the internet

In this roundup, we look back on our interviews with scientists who are making strides in developing...

All gene therapies have their own advantages and limitations, but one shared feature is the...

Some of the best stuff we picked up around the Internet

Genome editing and its potential uses are highly complex and can be challenging to comprehend for...

CRISPR is believed to hold the cure for many rare single-gene disorders that are otherwise...

Some of the best stuff we picked up around the Internet

When CRISPR-Cas9 was first adapted to eukaryotic genome editing in 2012, scientists worldwide...

Using massively parallel kinetic profiling, scientists can now characterise the cleavage and binding...

Some of the best stuff we picked up around the Internet

CRISPR genome editing marches forward as a curative therapy for genetic disorders. Here lead...

We have added a new cancer immunotherapy trial by CRISPR Therapeutics to our overview of current...

Some of the best stuff we picked up around the Internet

Scientists use CRISPR to change the fate of adipocytes, so bad fat is turned into good fat....

For CRISPR genome editing, it is important to consider what form the agent is delivered. In this...

Using 'dead' dCas9 fused to transcriptional activators researchers wake silent genes to alleviate...

Some of the best stuff we picked up around the Internet

We have added two cancer immunotherapy trials to our overview of current clinical trials involving...

As the coronavirus pandemic continues, scientists worldwide redeploy their resources to join the...