Researchers at the Francis Crick Institute in the UK recently discovered that CRISPR-Cas9 genome...

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Verve Therapeutics demonstrates preclinical proof-of-concept with support from Beam Therapeutics

With extremely precise gene repair scientist succesfully converts the mutated allele that causes...

A new deep learning model, CRISPRon, offers scientists more accurate gRNA on-target efficiency...

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This week we bring you a clinical trial update on GC027, a CRISPR-edited CAR T-cell therapy for...

Using microneedles for transdermal delivery of CRIPSR-Cas9 and glucocorticoids researchers have...

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This week’s update looks at a CRISPR-Cas12a-based detection method, developed in China as a...

Nicole Paulk is at the forefront of adeno-associated virus technology, often used for delivering...

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In this week’s update, we present a CRISPR-based therapy for sickle cell disease (SCD) that has...

Multiple new deals and developments and new base editor data from Intellia Therapeutics

Researchers from the University of Illinois at Chicago have developed a novel method to genetically...

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This week’s update looks at a Phase 1/2 study for ALLO-501A, a TALEN-edited CAR T-cell therapy for...

Editing a single nucleotide in the largest human gene is sufficient to restore dystrophin production...

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This week’s update looks at a CRISPR-edited CAR T-cell therapy in clinical development for the...

β-Thalassemia is caused in part by a mutated β-globin gene, so researchers developed a way to...

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This week’s update looks at a combined vaccine/CRISPR-edited T cell trial for prostate cancer, and a...

Researchers at University of Freiburg in Germany have developed the first assay to identify and...

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In this brief roundup, we look at what's going on in the CRISPR Medicine field for Leber congenital...

DNA repair by a hitherto overlooked mechanism - non-homologous blunt-end joining – might lead to a...

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Erik Sontheimer, Professor and Vice Chair at the RNA Therapeutics Institute and at the University of...

In recent years, researchers have turned to gene editing to address the limitations of CAR T...

Professor Jin-Soo Kim, from the Center for Genome Engineering at the Republic of Korea’s Institute...

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This week’s clinical update looks at 3 clinical trials for the treatment of sickle cell disease...

Almost complete efficiency of gene knock-in is achieved with a new CRISPR-based system developed by...

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This week’s clinical update looks at 3 clinical trials for CRISPR-edited CAR T therapies for the...

Pharmaceutical and biological research as well as biologics manufacturing rely on genetically...

A novel, highly potent lipid nanoparticle (LNP) CRISPR-Cas9 delivery system targets the liver more...

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This week’s clinical update looks at two clinical trials for beta thalassemia using...

The mechanism our immune system uses to fend off viruses also attacks AAV vectors. Adding telomeric...

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This week’s update looks at DA01, the first gene-edited cell therapy for Parkinson’s disease (PD) to...

The group of Mario Amendola has used CRISPR-based editing of haematopoietic stem cells to generate a...

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Locus Biosciences announced on Wednesday that it successfully completed the world's first clinical...

Andre Watson, the founder of the gene delivery platform company Ligandal, quickly pivoted his...

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CRISPR-Cas is seen as the holy grail in medicine for rare and incurable genetic diseases. In this...

DECODR's algorithm can quickly — and cheaply — make sense of Sanger sequencing data at a very...

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This week’s clinical update looks at a trial to evaluate a combined CRISPR-Cas12a/PCR detection...

A constant battle between prokaryotes and phages has shaped how CRISPR is controlled and regulated....

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This week’s update looks at a Phase 1 clinical trial for a new meganuclease-edited CAR T-cell...

At the beginning of a genome editing revolution one of the great challenges is the need for a common...

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A new generation of therapies based on CRISPR-Cas and other gene-editing technologies brings hope to...

Researchers can manipulate genomes at the single-base level, but they still struggle to predict and...

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This week’s gene-editing clinical trial update looks at a universal dual specificity CD19 and...

With a new IND in hand, Graphite Bio plans to begin clinical trials for a CRISPR treatment that will...

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This week’s IND update looks at two distinct gene-editing strategies for sickle cell disease, both...

Leber congenital amaurosis is a group of rare inherited retinal diseases that lead to blindness over...

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The CRISPR gene-editing therapy more than doubled the lifespan in a mouse model by tackling the root...

Kevin Davies, author and Executive Editor of The CRISPR Journal, says that CRISPR is as close as...

In this disease-oriented roundup, we take a look at clinical-stage gene-editing approaches to sickle...

This year CRISPR broke new ground in medicine. We saw the first CRISPR gene editing directly in the...

Update on Allogene Therapeutics off-the-shelf CAR-T cancer therapies. This week’s gene-editing...

A disease model using patients’ own cells demonstrates that prime editing can be used for functional...

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In this week’s clinical update, we look at three clinical-stage CRISPR-engineered cell therapies...

Lack of efficient delivery vehicles has so far hampered CRISPR-Cas9 editing in non-liver tumours....

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Just 8 years after the development of CRISPR-Cas technology, Vertex Pharmaceuticals and CRISPR...

The new electric field-driven 'lab-on-a-chip' use CRISPR-Cas12 to rapidly detect the SARS-CoV-2 in...

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Last week, we bought you our first IND update for a selection of gene-editing therapies currently...

CRISPR is set to change the face of medicine, and is already contributing to a huge number of...

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Clinical trials to assess the safety and medical benefit of CRISPR therapies are complex. This is...

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Researchers have shown that CRISPR-Cas9 knockout of CISH, a negative regulator of T cell immunity,...

We have added 4 new CRISPR-Cas trials to our overview of current clinical trials involving gene...

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We have added 6 new cancer trials to our overview of current clinical trials involving gene editing.

A CRISPR-Cas9 treatment reactivated a crucial gene in mice and human neurons — hinting at a possible...

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Professor Waseem Qasim, of University College London and Great Ormond Street Institute of Child...

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We have added three clinical trials to our comprehensive database of the current CRISPR-based trials...

Researchers found a highly efficient repressor for CRISPRi experiments, ZIM3, which can repress gene...

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Virtual event featured talk from recent Nobel Prize recipient Jennifer Doudna, as well as in-depth...

California-based gene-editing company Scribe Therapeutics recently unveiled its plans to develop the...

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With the Nobel Prize in Chemistry being awarded to the founding mothers of CRISPR - Emmanuelle...

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The Royal Swedish Academy of Sciences today awarded the Nobel Prize in Chemistry to Drs. Emmanuelle...

Our clinical trials database is a comprehensive collection of the current CRISPR-based trials for...

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Off-target editing is a significant problem with CRISPR and something that scientists really want to...

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In this roundup, we look back on our interviews with scientists who are making strides in developing...

All gene therapies have their own advantages and limitations, but one shared feature is the...