With a new IND in hand, Graphite Bio plans to begin clinical trials for a CRISPR treatment that will...

Some of the best stuff we picked up around the internet

This week’s IND update looks at two distinct gene-editing strategies for sickle cell disease, both...

Leber congenital amaurosis is a group of rare inherited retinal diseases that lead to blindness over...

Some of the best stuff we picked up around the internet

The CRISPR gene-editing therapy more than doubled the lifespan in a mouse model by tackling the root...

Kevin Davies, author and Executive Editor of The CRISPR Journal, says that CRISPR is as close as...

In this disease-oriented roundup, we take a look at clinical-stage gene-editing approaches to sickle...

Update on Allogene Therapeutics off-the-shelf CAR-T cancer therapies. This week’s gene-editing...

A disease model using patients’ own cells demonstrates that prime editing can be used for functional...

Some of the best stuff we picked up around the internet

In this week’s clinical update, we look at three clinical-stage CRISPR-engineered cell therapies...

Lack of efficient delivery vehicles has so far hampered CRISPR-Cas9 editing in non-liver tumours....

Some of the best stuff we picked up around the internet

Just 8 years after the development of CRISPR-Cas technology, Vertex Pharmaceuticals and CRISPR...

The new electric field-driven 'lab-on-a-chip' use CRISPR-Cas12 to rapidly detect the SARS-CoV-2 in...

Some of the best stuff we picked up around the internet

Last week, we bought you our first IND update for a selection of gene-editing therapies currently...

CRISPR is set to change the face of medicine, and is already contributing to a huge number of...

Some of the best stuff we picked up around the internet

Clinical trials to assess the safety and medical benefit of CRISPR therapies are complex. This is...

Some of the best stuff we picked up around the internet

Researchers have shown that CRISPR-Cas9 knockout of CISH, a negative regulator of T cell immunity,...

We have added 4 new CRISPR-Cas trials to our overview of current clinical trials involving gene...

Some of the best stuff we picked up around the internet

We have added 6 new cancer trials to our overview of current clinical trials involving gene editing.

A CRISPR-Cas9 treatment reactivated a crucial gene in mice and human neurons — hinting at a possible...

Some of the best stuff we picked up around the internet

Professor Waseem Qasim, of University College London and Great Ormond Street Institute of Child...

Some of the best stuff we picked up around the internet

We have added three clinical trials to our comprehensive database of the current CRISPR-based trials...

Researchers found a highly efficient repressor for CRISPRi experiments, ZIM3, which can repress gene...

Some of the best stuff we picked up around the internet

Virtual event featured talk from recent Nobel Prize recipient Jennifer Doudna, as well as in-depth...

California-based gene-editing company Scribe Therapeutics recently unveiled its plans to develop the...

Some of the best stuff we picked up around the internet

With the Nobel Prize in Chemistry being awarded to the founding mothers of CRISPR - Emmanuelle...

Some of the best stuff we picked up around the internet

The Royal Swedish Academy of Sciences today awarded the Nobel Prize in Chemistry to Drs. Emmanuelle...

Our clinical trials database is a comprehensive collection of the current CRISPR-based trials for...

Some of the best stuff we picked up around the internet

Off-target editing is a significant problem with CRISPR and something that scientists really want to...

Some of the best stuff we picked up around the internet

In this roundup, we look back on our interviews with scientists who are making strides in developing...

All gene therapies have their own advantages and limitations, but one shared feature is the...

Some of the best stuff we picked up around the Internet

Genome editing and its potential uses are highly complex and can be challenging to comprehend for...

CRISPR is believed to hold the cure for many rare single-gene disorders that are otherwise...

Some of the best stuff we picked up around the Internet

When CRISPR-Cas9 was first adapted to eukaryotic genome editing in 2012, scientists worldwide...

Using massively parallel kinetic profiling, scientists can now characterise the cleavage and binding...

Some of the best stuff we picked up around the Internet

CRISPR genome editing marches forward as a curative therapy for genetic disorders. Here lead...

We have added a new cancer immunotherapy trial by CRISPR Therapeutics to our overview of current...

Some of the best stuff we picked up around the Internet

Scientists use CRISPR to change the fate of adipocytes, so bad fat is turned into good fat....

For CRISPR genome editing, it is important to consider what form the agent is delivered. In this...

Using 'dead' dCas9 fused to transcriptional activators researchers wake silent genes to alleviate...

Some of the best stuff we picked up around the Internet

We have added two cancer immunotherapy trials to our overview of current clinical trials involving...

As the coronavirus pandemic continues, scientists worldwide redeploy their resources to join the...

CRISPR gene editing technology provides hope for cures for the 10,000 single gene disorders...

Researchers at UC Berkeley have discovered CasΦ, a small and highly compact CRISPR system in...

Some of the best stuff we picked up around the Internet

For the first time, scientists have seen high-resolution molecular details of a CRISPR-Cas9 base...

The first clinical trial results indicate that CRISPR is a safe and beneficial gene editing tool in...

Some of the best stuff we picked up around the Internet

We are at the beginning of a new era of gene editing where it is possible to edit any desired DNA...

Results from the first clinical trials using CRISPR in persons have been reported. The early first...

Kiana Aran talks about the first products in quality control for CRISPR gene-editing, and how she...

Some of the best stuff we picked up around the Internet

New data confirms CRISPR gene editing as a cure for sickle cell disease and β-thalassemia, though...

CRISPR holds the key to novel genetic therapies but safe and efficient delivery of CRISPR reagents...

Some of the best stuff we picked up around the Internet

During clinical development, science is turned into medicine. Data from basic research, pre-clinical...

Continuous advances in gene editing technologies provide hopes for better therapies and cures for...

Some of the best stuff we picked up around the Internet

New research opens the door to RNA editing therapies that can influence gene expression without...

For the first time, the FDA has authorized a CRISPR gene-editing tool - the COVID 19 diagnostic kit...

Advances in cellular and gene therapies are set to revolutionise modern medicine. However,...

Some of the best stuff we picked up around the Internet

Testing in numbers and speed are crucial to fighting the COVID19 pandemic. Now, a new CRISPR-based...

By combining peptide display and different AAV serotypes, researchers have learned how to make and...

Some of the best stuff we picked up around the Internet

The first CRISPR data from China is out. CRISPR-Cas9-edited T cells were investigated as a treatment...

For the first time, scientists can use gene therapy to correct a diabetes-causing mutation in stem...

As CRISPR moves closer to the clinic, it becomes clear that Cas9 won’t be the only tool in the...

Some of the best stuff we picked up around the Internet

CRISPR is set to revolutionise medicine, with clinical trials already underway for a number of...

News of CRISPR gene-editing in human patients is popping up all the time. It can be confusing and...

Some of the best stuff we picked up around the Internet

In a world's first, Locus Biosciences has enrolled the first patients in a clinical trial using...

CRISPR and organoids are transforming science and medicine, and now dutch scientists have used...

Some of the best stuff we picked up around the Internet

Marcello Maresca is an associate director at AstraZeneca, leading the team of Precise genome...

In November, researchers announced the results of the first US CRISPR gene therapy. Now the data are...

A new principle of kinetic insulation via anti-CRISPR proteins is a highly versatile approach to...

Gene therapy stops deadly chemical warfare nerve agents in mice. The new research could lead to...

Some of the best stuff we picked up around the Internet

Prime editing made the Nature top 10 papers of 2019 with a Nature paper describing a new CRISPR tool...

Some of the best stuff we picked up around the Internet

They solved the CRISPR Cas12a structure, discovered how the unique Cas12a enzyme cuts DNA, and are...

Some of the best stuff we picked up around the Internet

A new CRISPR/Cas9 research center, PASCAL-MID, aims to lay the foundation for future gene therapies...

While CRISPR has taken the world by storm, a small Israeli company, TargetGene Biotechnologies, has...

Some of the best stuff we picked up around the Internet

Bugs are winning: WHO has issued dire warnings of 'the post-antibiotic era' in which any person...

Safe and efficient delivery tools are crucial for succesful gene therapy. Adeno-associated virus...

Some of the best stuff we picked up around the Internet

Jason Potter (ThermoFisher) was around when PCR came about and says it was just like the CRISPR...

Safety director Roberto Nitsch, AstraZeneca, discusses the key safety aspects of delivering...

Some of the best stuff we picked up around the Internet

Kevin Holden of Synthego discusses automation and large data-sets as a way to best practices in gene...

Samantha Maragh, US National Institute of Standards and Technology (NIST), discusses how the CRISPR...