Controllable Genome Editing With Split-Engineered Base Editors | Wed. April 27, 2022 | 3:00 pm – 4:30 pm CEST / 9:00 am – 10:30 am EST | Free CMN Live Webinar
On-demand webinar is available - Follow this link
Controllable Genome Editing With Split-Engineered Base Editors
Base-editing systems have been hailed as safer alternatives to traditional CRISPR-Cas9 gene editing, primarily because they can induce point mutations without creating double-stranded breaks.
Despite the clear potential of base editors systems in correcting single nucleotide polymorphisms (SNPs) - which cause a majority of human genetic diseases - a major stumbling block in the therapeutic application of base editors (BEs) is their off-target activity.
In a study published late last year in Nature Chemical Biology, a team of researchers from Associate Professor Rahul Kohli’s lab at the University of Pennsylvania reveal the first controllable base-editing system. In this webinar, lead author Kiara N. Berríos will present the group's work and findings on split-engineered base editors.
What will you learn from this webinar:
- Learn about the physiological functions and malfunctions of DNA deaminases
- Learn how the development of split-DNA deaminases allow for small molecule control over their activity for base editing applications and more
- Learn how regulation over DNA deaminase activity in split-engineered base editors decrease off-target effects and allow temporal control over genome editing
Tentative Webinar Programme:
- 15.00 Welcome and introduction by CRISPR Medicine News
- 15.05 Kiara N. Berríos, Ph.D. in Biochemistry and Molecular Biophysics, University of Pennsylvania, USA | Controllable Genome Editing with Split-engineered Base Editors
- 15.50 Q & A with Kiara N. Berríos,
- 16.25 Close by CRISPR Medicine News
Speaker | Title:
Kiara N. Berríos, Ph.D. in Biochemistry and Molecular Biophysics, University of Pennsylvania, USA | Controllable Genome Editing with Split-engineered Base Editors
Kiara N. Berríos, Ph.D. in Biochemistry and Molecular Biophysics, University of Pennsylvania, USA
Kiara N. Berríos received a B.S. in Chemistry from the University of Puerto Rico, Río Piedras campus in May 2016. In April 2022, she received her Ph.D. in Biochemistry and Molecular Biophysics from the University of Pennsylvania where she studied the mechanism of DNA deaminases in base-editing systems under the mentorship of Rahul M. Kohli. During her Ph.D. research, Kiara was supported by an individual fellowship from the National Science Foundation (NSF-GRFP). She will soon join the laboratory of David R. Liu as a postdoctoral researcher.
Read our CMN interview with Dr. Berríos from 2021.
Interested in hosting a webinar on CMN?
Contact us to learn more about our Client Webinar package.
+20k readers | +10k followers | Top-1 CRISPR News Site | email@example.com
CMN Webinars - Your Gateway to CRISPR Medicine
If you have any questions or request for webinars, please contact us at: firstname.lastname@example.org
Future CMN Webinars will be listed here.
Always stay updated - Sign up to weekly newsletter.
CMN Articles - Base Editors