CRISPR CLINICAL TRIALS

Medicine is changing.

New CRISPR gene editing clinical studies are rapidly emerging and we think a comprehensive overview is valuable to help keep track of them all.

CRISPR is the hot new rapidly rising gene editing tool but we also include clinical trials of other gene editing modalities like the Zinc Finger Nucleases, TALENs, MegaTALS, MegaNucleases and any new variants that will be out there in the future. We will keep updating our overview.

Check already now the world's-first clinical trial for a CRISPR-Cas3 phage therapy for treatment of urinary tract infections, developed by Locus BioSciences and get all the details about their unique technology from this interview with VP, Business Development, Joseph Nixon.

The clinical trials are arranged in the following areas: Antibacterials, Blood, Cancer, Eye and Metabolic disorders.

CRISPR-Cas | TALENS | ZFN

Therapeutics

Antibacterial

Urinary Tract Infections, UTI, (NCT04191148)

Open access

Sponsors:
Locus Biosciences

Pre-clinical

Phase I

Phase II

Phase III

Blood

Beta-Thalassemia, (NCT03655678)
Sponsors:
Vertex Pharmaceuticals Incorporated

Pre-clinical

Phase I

Phase II

Phase III

Hemophilia B Factor IX, (2017-004805-42)
Sponsors:
Sangamo Therapeutics, Inc.

Pre-clinical

Phase I

Phase II

Phase III

Hemophilia B, (NCT02695160)
Sponsors:
Sangamo Therapeutics, Inc.

Pre-clinical

Phase I

Phase II

Phase III

Human Immunodeficiency Virus Infection, HIV (NCT02388594)
Sponsors:
University of Pennsylvania

Pre-clinical

Phase I

Phase II

Phase III

Human Immunodeficiency Virus Infection, HIV, (NCT00842634)
Sponsors:
University of Pennsylvania

Pre-clinical

Phase I

Phase II

Phase III

Human Immunodeficiency Virus Infection, HIV, (NCT01044654)
Sponsors:
Sangamo Therapeutics Inc.

Pre-clinical

Phase I

Phase II

Phase III

Human Immunodeficiency Virus Infection, HIV, (NCT01252641)
Sponsors:
Sangamo Therapeutics Inc.

Pre-clinical

Phase I

Phase II

Phase III

Human Immunodeficiency Virus Infection, HIV, (NCT02225665)
Sponsors:
Sangamo BioSciences, Inc.

Pre-clinical

Phase I

Phase II

Phase III

Human Immunodeficiency Virus Infection, HIV, (NCT02500849)
Sponsors:
City of Hope Medical Center

Pre-clinical

Phase I

Phase II

Phase III

Human Immunodeficiency Virus Infection, HIV, (NCT03164135)
Sponsors:
Affiliated Hospital to Academy of Military Medical Sciences

Pre-clinical

Phase I

Phase II

Phase III

Human Immunodeficiency Virus Infection, HIV, (NCT03617198)
Sponsors:
University of Pennsylvania

Pre-clinical

Phase I

Phase II

Phase III

Human Immunodeficiency Virus Infection, HIV, (NCT03666871)
Sponsors:
Case Western Reserve University

Pre-clinical

Phase I

Phase II

Phase III

Sickle Cell Disease, SCD, (NCT03653247)
Sponsors:
Bioverativ, a Sanofi company

Pre-clinical

Phase I

Phase II

Phase III

Sickle Cell Disease, SCD, (NCT03745287)
Sponsors:
Vertex Pharmaceuticals Incorporated

Pre-clinical

Phase I

Phase II

Phase III

Transfusion Dependent Beta-Thalassemia, TDT, (NCT03432364)
Sponsors:
Sangamo Therapeutics, Inc.

Pre-clinical

Phase I

Phase II

Phase III

Cancer

Acute Lymphoblastic Leukemia, ALL, (NCT04037566)
Sponsors:
Xijing Hospital, The Fourth Military Medical University

Pre-clinical

Phase I

Phase II

Phase III

Acute Myeloid Leukaemia, AML, (NCT04106076)
Sponsors:
Cellectis S.A.

Pre-clinical

Phase I

Phase II

Phase III

Acute Myeloid Leukemia, AML, (NCT03190278)
Sponsors:
Cellectis S.A.

Pre-clinical

Phase I

Phase II

Phase III

Advanced Hepatocellular Carcinoma, HCC, (NCT04417764)
Sponsors:
Central South University

Pre-clinical

Phase I

Phase II

Phase III

B Cell Malignancy, NHL, (NCT03166878)
Sponsors:
Chinese PLA General Hospital

Pre-clinical

Phase I

Phase II

Phase III

B- cell Acute Lymphoblastic Leukaemia, ALL, (2019-003462-40)
Sponsors:
Great Ormond Street Hospital for Children NHS Trust

Pre-clinical

Phase I

Phase II

Phase III

B-cell Acute Lymphoblastic Leukemia, ALL, (NCT04150497)
Sponsors:
Cellectis S.A.

Pre-clinical

Phase I

Phase II

Phase III

B-cell Malignancy, NHL, (NCT04035434)
Sponsors:
CRISPR Therapeutics AG

Pre-clinical

Phase I

Phase II

Phase III

Bladder Cancer, Invasive, IBC, (NCT02863913)
Sponsors:
Peking University

Pre-clinical

Phase I

Phase II

Phase III

Esophageal Cancer, (NCT03081715)
Sponsors:
Hangzhou Cancer Hospital

Pre-clinical

Phase I

Phase II

Phase III

Gastro-Intestinal Cancer, GI, (NCT04426669)
Sponsors:
Intima Bioscience, Inc.

Pre-clinical

Phase I

Phase II

Phase III

Human papillomavirus (HPV) related cervical cancer, (NCT02800369)
Sponsors:
Huazhong University of Science and Technology

Pre-clinical

Phase I

Phase II

Phase III

Human papillomavirus (HPV) related cervical cancer, (NCT03057912)
Sponsors:
First Affiliated Hospital, Sun Yat-Sen University

Pre-clinical

Phase I

Phase II

Phase III

Human papillomavirus (HPV) related cervical cancer, (NCT03226470)
Sponsors:
Huazhong University of Science and Technology

Pre-clinical

Phase I

Phase II

Phase III

Metastatic Non-small Cell Lung Cancer, NSCLC, (NCT02793856)
Sponsors:
Sichuan University

Pre-clinical

Phase I

Phase II

Phase III

Multiple Myeloma, MM, (NCT03399448)
Sponsors:
University of Pennsylvania

Pre-clinical

Phase I

Phase II

Phase III

Multiple Myeloma, MM, (NCT04093596)
Sponsors:
Allogene Therapeutics

Pre-clinical

Phase I

Phase II

Phase III

Multiple Myeloma, MM, (NCT04142619)
Sponsors:
Cellectis S.A.

Pre-clinical

Phase I

Phase II

Phase III

Multiple Myeloma, MM, (NCT04244656)
Sponsors:
CRISPR Therapeutics AG

Pre-clinical

Phase I

Phase II

Phase III

Multiple Solid Tumor Adult, (NCT03545815)
Sponsors:
Chinese PLA General Hospital

Pre-clinical

Phase I

Phase II

Phase III

Nasopharyngeal Carcinoma, (NCT03044743)
Sponsors:
Yang Yang, MD, PhD, MSCR, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Pre-clinical

Phase I

Phase II

Phase III

Non-Hodgkin Lymphoma, NHL, (2018-003916-38)
Sponsors:
CRISPR Therapeutics AG

Pre-clinical

Phase I

Phase II

Phase III

Non-Hodgkin Lymphoma, NHL, (NCT03939026)
Sponsors:
Allogene Therapeutics

Pre-clinical

Phase I

Phase II

Phase III

Renal Cell Carcinoma, (NCT04438083)
Sponsors:
CRISPR Therapeutics AG

Pre-clinical

Phase I

Phase II

Phase III

Solid Tumor Adult, (NCT03747965)
Sponsors:
Chinese PLA General Hospital

Pre-clinical

Phase I

Phase II

Phase III

T Cell Lymphoma, (NCT04502446)
Sponsors:
CRISPR Therapeutics AG

Pre-clinical

Phase I

Phase II

Phase III

T-cell Acute Lymphoblastic Leukemia, ALL, (NCT03690011)
Sponsors:
Baylor College of Medicine

Pre-clinical

Phase I

Phase II

Phase III

Eye

Leber Congenital Amaurosis, (NCT03872479)
Sponsors:
Allergan

Pre-clinical

Phase I

Phase II

Phase III

Metabolic disorder

Mucopolysaccharidosis type II, MPS II, (2018-000192-33)
Sponsors:
Sangamo Therapeutics, Inc.

Pre-clinical

Phase I

Phase II

Phase III

Mucopolysaccharidosis I, MPS I, (2018-000206-28)
Sponsors:
Sangamo Therapeutics, Inc.

Pre-clinical

Phase I

Phase II

Phase III

Mucopolysaccharidosis II, MPS II, (NCT03041324)
Sponsors:
Sangamo Therapeutics Inc.

Pre-clinical

Phase I

Phase II

Phase III

Mucopolysaccharidosis type I, MPS I, (NCT02702115)
Sponsors:
Sangamo Therapeutics Inc.

Pre-clinical

Phase I

Phase II

Phase III

Diagnostics

Human Enterovirus Infections, HEV, (NCT04535648)
Sponsors:
Children's Hospital of Fudan University

Pertussis -Whooping Cough, (NCT04535505)
Sponsors:
Children's Hospital of Fudan University