A solid tumour is an abnormal mass of tissue that usually does not contain cysts or liquid areas. Solid tumours may be benign (not cancer), or malignant (cancer). Solid tumour types are named according to the type of cell they originate from. Examples of solid tumours include sarcomas, carcinomas, and lymphomas. Leukaemias (cancers of the blood) generally do not form solid tumours.
United States, California
The Angeles Clinic and Research Institute: Recruiting
Los Angeles, California, United States, 90025
United States, Florida
Orlando Health Cancer Institute: Recruiting
Orlando, Florida, United States, 32610
United States, Kansas
The University of Kansas Cancer Center: Recruiting
Westwood, Kansas, United States, 66205
United States, Kentucky
University of Louisville: Recruiting
Louisville, Kentucky, United States, 40202
United States, New York
Memorial Sloan Kettering Cancer Center: Recruiting
New York, United States, 10065
United States, Ohio
University of Cincinnati: Recruiting
Cincinnati, Ohio, United States, 45219
United States, Wisconsin
Medical College of Wisconsin: Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Iovance Biotherapeutics Study Team866-565-4410 Clinical.Inquiries@iovance.com
Status: Active recruiting
Description
This study is the first-in-human study of IOV-4001, a genetically modified autologous tumour-infiltrating lymphocyte (TIL) product. IOV-4001 is expected to exert anti-tumour activity through its capacity to directly target and kill tumour cells in a manner that is similar to non-genome-edited TILs, but with the potential for enhanced anti-tumour activity through disruption of the PDCD1 gene, which encodes programmed cell death protein-1 (PD-1).
Last updated: Jun. 5, 2023