A recent breakthrough in gene-editing technology introduces circular RNA-mediated prime editors (CPEs), harnessing the Cas12a system to offer an...

Researchers report the treatment of a genetic liver disease in mice through transient prime editor expression.

Prime editors combine the DNA-scanning capabilities of CRISPR-Cas with a reverse transcriptase enzyme to introduce single-base edits in DNA without...

Prime editing combines the powerful DNA-scanning and sequence-identification capabilities of the CRISPR-Cas9 system with a reverse transcriptase...

Gene editing has revolutionised research and is set to change the treatment landscape for genetic diseases, with >100 ongoing clinical trials across...

At a length of around 100 nucleotides, single guide RNAs are not synthesised efficiently. However, thanks to click chemistry, they can now be...

A CRISPR-based therapy for the metabolic liver disease phenylketonuria (PKU) has moved one step forward. In vivo prime editing in neonate mice...

2021 was a very successful year for CRISPR in the medical field. Much of the success comes down to gene editing without double-strand breaks,...