Off-target

A new computational framework called CCLMoff uses deep learning and RNA language models to predict off-target effects in CRISPR-CAS9 genome editing...

Researchers in Korea report that large DNA deletions occur during DNA repair at a much lower frequency for base editors and prime editors than for...

Researchers in Israel have introduced CRISPECTOR2.0, an enhanced version of the CRISPECTOR tool. CRISPECTOR2.0 offers improved accuracy by integrating...

Researchers have used an energy-based model to identify mechanisms regulating CRISPR-Cas9 activity and specificity. They found that local gRNA-DNA...

Two critical points in evaluating the effects of CRISPR gene-editing experiments are validation of intended on-target modifications and testing for...