Off-target

| CRISPR Medicine | This is an overview of articles on off-target

Sign-up to weekly Newsletter here.

CRISPR-Cas9 Causes Unintended On-Target Mutations...

Jun. 7, 2021

Researchers at the Francis Crick Institute in the UK recently discovered that CRISPR-Cas9 genome editing in early human embryos led to large...

Jan Gorodkin (left) is at the University of Copenhagen, Denmark. Yonglon Luo (right) is at Aarhus...

New Tool Offers Better Prediction of gRNA...

May. 31, 2021

A new deep learning model, CRISPRon, offers scientists more accurate gRNA on-target efficiency predictions than other existing tools. Massive,...

Simplest Possible Modification Rescues Dystrophin...

May. 3, 2021

Editing a single nucleotide in the largest human gene is sufficient to restore dystrophin production and myocyte function in Duchenne muscular...

Webinar

Certainty After CRISPR

Apr. 20, 2021

The Certainty After CRISPR Webinar is now available On-demand for CMN+ Subscribers

CAST-Seq: A New and Much-Needed Tool for Assessing...

Apr. 19, 2021

Researchers at University of Freiburg in Germany have developed the first assay to identify and quantify unintended chromosomal rearrangements at on-...

3D illustration concept of human liver anatomy. Credit: magicmine.

In Vivo CRISPR Treatment Cuts Blood Cholesterol by...

Mar. 15, 2021

A novel, highly potent lipid nanoparticle (LNP) CRISPR-Cas9 delivery system targets the liver more efficiently than previous methods. Used in...

New App Can Reveal Unintentional Mutations of a...

Feb. 15, 2021

DECODR's algorithm can quickly — and cheaply — make sense of Sanger sequencing data at a very precise level.

Haridha Shivram is Postdoctoral Researcher in Jennifer Doudna’s lab at University of California,...

An Arms Race Can Make the CRISPR Toolkit Even...

Feb. 8, 2021

A constant battle between prokaryotes and phages has shaped how CRISPR is controlled and regulated. Haridha Shivram from Jennifer Doudna’s lab is...