Off-target

| CRISPR Medicine | This is an overview of articles on off-target

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New App Can Reveal Unintentional Mutations of a...

Feb. 15, 2021

DECODR's algorithm can quickly — and cheaply — make sense of Sanger sequencing data at a very precise level.

Haridha Shivram is Postdoctoral Researcher in Jennifer Doudna’s lab at University of California,...

An Arms Race Can Make the CRISPR Toolkit Even...

Feb. 8, 2021

A constant battle between prokaryotes and phages has shaped how CRISPR is controlled and regulated. Haridha Shivram from Jennifer Doudna’s lab is...

Indel Detection is the ‘Achilles Heel’ of Precise...

Jan. 25, 2021

Researchers can manipulate genomes at the single-base level, but they still struggle to predict and detect the editing outcomes precisely. Eric Paul...

The Future of CRISPR, As Kevin Davies Sees It

Jan. 4, 2021

Kevin Davies, author and Executive Editor of The CRISPR Journal, says that CRISPR is as close as doctors may be able to get to the Holy Grail of...

Prime Editing Restores Function of Genetic Defects...

Dec. 21, 2020

A disease model using patients’ own cells demonstrates that prime editing can be used for functional repair of mutations leading to metabolic...

Spatio-Temporal Control of CRISPR Editing With...

Nov. 30, 2020

CRISPR is set to change the face of medicine, and is already contributing to a huge number of clinical trials for a broad range of diseases....

Safety is Key to Novel CRISPR Medicines

Oct. 12, 2020

With the Nobel Prize in Chemistry being awarded to the founding mothers of CRISPR - Emmanuelle Charpentier and Jennifer Doudna - genome editing is...

Truncated guide RNAs Protect Off-Target Sites from...

Oct. 2, 2020

Off-target editing is a significant problem with CRISPR and something that scientists really want to protect genomes from. And protection is exactly...