Off-target

Researchers have used an energy-based model to identify mechanisms regulating CRISPR-Cas9 activity and specificity. They found that local gRNA-DNA...

Two critical points in evaluating the effects of CRISPR gene-editing experiments are validation of intended on-target modifications and testing for...

For the first time, adverse translocation events can be detected in multiplex PCR experiments after CRISPR editing. A new software tool, CRISPECTOR,...

Researchers at the Francis Crick Institute in the UK recently discovered that CRISPR-Cas9 genome editing in early human embryos led to large...

A new deep learning model, CRISPRon, offers scientists more accurate gRNA on-target efficiency predictions than other existing tools. Massive,...