HIV stands for human immunodeficiency virus. It harms the immune system by destroying the white blood cells that fight infection. This puts at risk for serious infections and certain cancers.
HIV stands for human immunodeficiency virus. It harms the immune system by destroying the white blood cells that fight infection. This puts at risk for serious infections and certain cancers.
Principal Investigator: Hu Chen, MD, PhD Affiliated Hospital of Academy to Military Medical Sciences
Principal Investigator: Hongkui Deng, PhD Affiliated Hospital of Academy to Military Medical Sciences
Principal Investigator: Hao Wu, MD, PhD Affiliated Hospital of Academy to Military Medical Sciences
Affiliated Hospital to Academy of Military Medical Sciences
China, Beijing
Status: Active recruiting
Description
The investigators performed this study to evaluate the safety and feasibility of transplantation with CRISPR-Cas9 CCR5 gene modified CD34+ hematopoietic stem/progenitor cells for patients that develop AIDS and hematological malignances. Patients will be treated with antiviral therapy (ART) to achieve undetectable HIV-1 virus in peripheral blood before conditioning. CD34+ cells from donors will be infused into the patients after treatment with CRISPR-Cas9 to ablate CCR5 gene.
Last updated: Apr. 10, 2022