Clinical Trial

Disease: Solid Tumors, (NCT04551885)

Disease info:

A solid tumor is an abnormal mass of tissue that usually does not contain cysts or liquid areas. Solid tumors may be benign (not cancer), or malignant (cancer). Solid tumor types are named according to the type of cell they originate from. Examples of solid tumors are sarcomas, carcinomas, and lymphomas. Leukaemias (cancers of the blood) generally do not form solid tumours. 

The word tumor does not always imply cancer. In discussing tumors that are malignant (cancerous), however, the term solid tumor is used to distinguish between a localized mass of tissue and leukemia.

More than 1.9 million new cancer cases are expected to be diagnosed in the US in 2023.
Official title:
A Phase I, Open-Label, Multicenter Study of FT516 in Combination With Monoclonal Antibodies in Subjects With Advanced Solid Tumors

United States, Minnesota 
University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, United States, 55455

United States, New Jersey 
Hackensack University Medical Center/John Theurer Cancer Center, Hackensack, New Jersey, United States, 07601

United States, Texas 
MD Anderson Cancer Center, Houston, Texas, United States, 77030

Study start:
Sep. 7, 2020
12 participants
Gene editing method:
Type of edit:
Gene enhancement
Delivery method:
- Ex-vivo
This study was terminated by the Sponsor.
IND Enabling Pre-clinical
Phase I Safety
Phase II Safety and Dosing
Phase III Safety and Efficacy

Status: Terminated


This is a Phase 1 dose-finding study of FT-516 in combination with monoclonal antibodies in participants with advanced solid tumors. The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.

Last updated: Feb. 5, 2024
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