CRISPR Medicine News, 27 August 2020 | CRISPR cure for obesity? - CRISPR Medicine

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Can CRISPR cure obesity?

With a novel and promising type of CRISPR gene therapy, we may be getting closer to a CRISPR cure for obesity. Scientists at Joslin Diabetes Center Harvard Medical School use dCas9 fused to transcriptional activators to change the fate of adipocytes. They use CRISPR to activate one silent gene in 'bad' white fat cells that turns the cells turn into 'good' fat-burning brown-like adipocytes. Mice transplanted with these cells gained less weight and displayed up to 35% improvements in glucose tolerance and insulin sensitivity compared to controls. Read the full story here.

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