A gene-edited pig kidney kept a patient with end-stage kidney disease dialysis-free for 271 days, then failed and was removed without leaving the...
Rationally engineered chimeric attachment sites raise the efficiency with which the serine integrase Bxb1 inserts large DNA cassettes into targeted...
Delivering CRISPR-Cas9 as mRNA in lipid nanoparticles preserved the fitness and erythroid potential of edited human haematopoietic stem and progenitor...
A single intravenous dose of the CRISPR-Cas9 therapy CTX310 – developed by CRISPR Therapeutics – held circulating ANGPTL3, triglycerides and LDL...
A biodegradable charge-altering releasable transporter (CART) delivered RNA selectively to the corneal endothelium after injection into the anterior...
Genome-wide CRISPR-Cas9 screens identified hundreds of genes that support or restrict cGAS–STING-induced type I interferon expression in human...
A new CRISPR-Cas-derived base editor can simultaneously mutates adenine, cytosine and guanine within the same DNA allele. The system generated diverse...
US regulators have granted RMAT and Fast Track designations to Allogene’s TALEN-edited, allogeneic CD19 CAR T-cell therapy cema-cel for first-line...
