Clinical Trial

Disease: Acute Myeloid Leukemia, AML, (NCT05309733)

Disease info:

Leukaemia is cancer of the white blood cells. White blood cells help your body to fight infection. Your blood cells form in your bone marrow. In leukaemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute myeloid leukaemia (AML), there are too many of a specific type of white blood cell called a myeloblast.

AML is the most common type of acute leukaemia in adults. This type of cancer usually gets worse quickly if it is not treated. 

Frequency:
The estimated number of new cases of acute myeloid leukaemia is 4.3 per 100,000 men and women per year. The estimated number of deaths is 2.8 per 100,000 men and women per year. These rates are age-adjusted and based on 2012-2016 cases and deaths.
Official title:
A Long-term Follow-up Study of Patients Who Received VOR33
Partners:
Locations:

United States, California

United States, Florida

United States, Missouri

United States, New Jersey

United States, New York

United States, Ohio

United States, Washington

Canada, Quebec

Study start:
Apr. 15, 2022
Enrollment:
36
Gene editing method:
CRISPR-Cas9
Type of edit:
Gene knock-out
Gene:
CD33 molecule
Delivery method:
Undisclosed. - Ex-vivo
IndicatorIndicator
IND Enabling Pre-clinical
Phase I Safety
Phase II Safety and Dosing
Phase III Safety and Efficacy

Status: Enrolling by invitation

Description

VBP201 study is the VOR33 long-term follow-up (LTFU) study focusing on assessing long-term safety and efficacy of VOR33. This study may last up to 15 years (counted from the date of VOR33 infusion completion). All patients who have participated in a study involving the drug product VOR33 and have completed the applicable study or prematurely discontinued, but have at least received the VOR33 infusion, will be asked to participate in the LTFU study.

Last updated: May. 2, 2022
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