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CARBON Newsletter (27 July) - Your Latest News About CRISPR in AgroBio

Some of the best links we picked up around the internet

By: Gorm Palmgren - Jul. 27, 2022

CRISPR AgroBio News (CARBON) is a new initiative from CRISPR Medicine News. CARBON will bring you the latest news on how CRISPR can shape agriculture for the future to guarantee food security in times of population growth and climate change.

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Top picks

  • Researchers in Spain have developed two simple and effective CRISPR-based methods for detecting infection with three common RNA viruses in Nicotiana benthamiana plants. In one setting, Cas13a was used in crude leaf extracts without prior amplification together with crRNA targeting either Tobacco mosaic virus, Tobacco etch virus or Potato virus X. Upon detection of the viral RNA, collateral cleavage of an ssRNA probe labelled with a fluorophore and a quencher led to fluorescence readout. In another setting, Cas12a was used similarly after PCR or isothermal amplification, and this method could also be used for multiplexed detection in plants with mixed infections.
  • Agroinfection with a potato virus X (PVX)-derived vector has been used to deliver part of the CRISPR toolkit to Nicotiana benthamiana. The Spanish researchers behind the achievement used the vector to deliver gRNAs to plants already transformed with the remaining complementary CRISPRa components that mediate strong programmable transcriptional activation in plants. After spraying N. benthamiana leaves with the virus vector, the gRNAs mediated a strong activation response in different target genes that moved locally and systemically.

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News: CARBON Newsletter (27 July) - Your Latest News About CRISPR in AgroBio
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