CMN Weekly (18 August 2023) - Your Weekly CRISPR Medicine News

Some of the best links we picked up around the internet

By: Gorm Palmgren - Aug. 18, 2023
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#CRISPRMED24

Top picks

  • Inspired by viral invasion, American researchers have engineered a DNA framework that can control CRISPR-Cas9. The DNA framework state machine (DFSM) can navigate living cells with temporal Precision, and by responding to specific molecular cues, the DFSM can assume multiple reversible structural states. Notably, this enables controlled CRISPR-Cas9 targeting of chromatin loci, illuminating prospects for intelligent theranostics in complex biological environments.
  • American scientists have utilized CRISPR-Cas9 to treat dominant hearing loss mutations. Using a mouse model, they employed liposome-mediated delivery to edit the responsible gene, Atp2b2. In double-mutation cases, this leads to outer hair cell survival, functional recovery, and even partial restoration. This breakthrough paves the way for gene editing as a potential treatment for hearing loss.

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Huh, heh, wow

  • A News story in Nature Biotechnology unfolds how a new generation of companies is using CRISPR to upgrade the production of insect larvae as a protein source for animal feed, fertilizer, biofuels and even as ingredients for burgers and shakes. CRISPR gene editing is used for yielding strains with higher lipid content, custom proteins, larger larvae, a more extended larval period and increased resilience under stress.
  • A News & Views article in Nature Microbiology discusses CRISPR-influenced symbiosis in archaea. CRISPR systems canonically confer microorganisms protection against invading viral DNA, plasmids and mobile genetic elements. However, a new multi-omics investigation of deep subsurface archaeal communities suggests that archaeal CRISPR systems might target other archaeal parasites or force a transition from parasitism to mutualism.

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News: CMN Weekly (18 August 2023) - Your Weekly CRISPR Medicine News
News: CMN Weekly (18 August 2023) - Your Weekly CRISPR Medicine News
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