CMN Weekly (20 May 2022) - Your Weekly CRISPR Medicine News
Some of the best links we picked up around the internet
By: Gorm Palmgren - May. 20, 2022
CRISPR gene editing is now possible in cockroaches (Blattella germanica). The Japanese and Spanish researchers used the straightforward and effective "direct parental" CRISPR (DIPA-CRISPR) procedure that involves injecting materials into female adults where eggs are developing rather than into the embryos themselves. The authors believe that the same approach can be used to gene edit more than 90% of insect species.
Researchers in China describe an advanced system for spatial-controlled RNA editing and precise cancer therapy. The system employs self-uncloaking CRISPR-Cas13a–customised RNA nanococoons (RNCOs-D), featuring tumour-specific recognition and spatial-controlled activation of Cas13a. NCOs-D consists of programmable RNA nanosponges (RNSs) capable of targeted delivery and nanocapsules (NCs) anchored on RNSs for cloaking Cas13a/crRNA ribonucleoprotein activity.
A review by scientists from India seeks to decrypt the mechanistic basis of the CRISPR-Cas9 protein. The authors discuss how a better understanding of the structural and sequence-based understanding of the whole CRISPR-associated bacterial ortholog family landscape and the underlying energetics of the CRISPR-Cas9 system can reveal critical parameters to design better CRISPR-Cas9s.
Monday's feature was about the successful use of CRISPR-Cas9 to selectively disrupt a mutant PSEN1 allele that causes familial Alzheimer’s disease. We interviewed Evangelos Konstantinidis, the first author of the proof-of-concept study, showing that gene editing in human fibroblasts may reverse Alzheimer's disease phenotypes by reducing the accumulation of extracellular amyloid-β deposits.
Our sister-site CRISPR AgroBio News (CARBON) launched its bi-weekly newsletter on Tuesday with links to recent news from CRISPR in agriculture. The top story was the introduction of a single base mutation in SOC1 in lettuce that delayed bolting, i.e., when crops put on a vertical growth spurt to flower and set seed before the vegetables are ready for harvest.
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