CMN Weekly (25 June 2021)

Some of the best links we picked up around the internet

By: Gorm Palmgren - Jun. 25, 2021

Top picks

Research

Industry

COVID-19

  • ERASE is a new customised CRISPR lateral flow strip for use in a simple, rapid, ultrasensitive, and highly specific assay for SARS-CoV-2 detection. ERASE can detect down to 1 copy/μL with 90.7% positive predictive agreement and 99.2% negative predictive agreement.
  • A review looks at the various methods for using CRISPR-Cas13-based platforms for COVID-19 diagnostics. Detailed and illustrated descriptions of assays like SHERLOCK, SHINE and CREST are given as well as a discussion of challenges and opportunities of point-of-care testing by CRISPR-Cas13 sensors.

Reviews

Opinion

  • "When is it Safe to Edit the Human Germline" is the title of a philosophical study by Janella Baxter, a PhD in philosophy. Baxter sets off with Jiankui He's two CRISPR babies and argues that the recent policy proposals to regulate human germline gene editing are inadequate.

Videos and tidbits

Heh, huh, wow

  • CRISPR-Act3.0 is a new robust CRISPR activation system for simultaneous activation of multiple genes in plants, namely rice, Arabidopsis and tomato. CRISPR-Act3.0 is based on dCas9 and a sgRNA scaffold that includes several MS2 RNA aptamers that can bind multiple VP64-activators. Up to seven genes could be detected simultaneously, and activation was fourfold to sixfold higher than other state-of-the-art systems.
  • The first CRISPR-Cas9-based gene drive system has been developed for plants. The method enables the transmission of targeted traits from a single parent in subsequent generations and allows for fast breeding of homozygous F1 crops.

Tags

HashtagArticleHashtagMissing linksHashtagNewsHashtagCMN Weekly

CLINICAL TRIALS
Indicator
IND Enabling
Phase I
Phase II
Phase III
Multiple myeloma, MM (NCT04960579)
Sponsors:
Poseida Therapeutics, Inc.
Indicator
IND Enabling
Phase I
Phase II
Phase III
IndicatorIndicator
IND Enabling
Phase I
Phase II
Phase III
View all clinical trials
close
Search CRISPR Medicine