Your missing links are here (17 April 2020)
By: Rasmus Kragh Jakobsen - Apr. 17, 2020
Top Picks
- Testing and speed are essential for stopping the COVID19 pandemic. Thursday the first CRISPR-based COVID19 detection technology was published by Charles Chui in Nature Biotechnology and is much faster than the standard method. Also here.
- Here is an overview of two teams developing CRISPR-based detection of COVID19.
- And if You just need one stop the Data Journalism team at the Financial Times do a fantastic job of crunching the numbers.
More COVID19
- CRISPR pioneer Jennifer Doudna opens lab to run Covid-19 tests.
Old-school video-game PACMAN gets a whole new twist. In a Cell pre-proof scientist at Stanford have developed a CRISPR-Cas13 strategy for shredding COVID19 in human lung epithelial cells.
Video interview with CRISPR and genomics-pioneer George Church on COVID19, future trends and more.
Research
- A CRISPR-based assay for the detection of opportunistic infections from simple urine sampling is a quick and easy way to monitor immunosuppressed kidney transplant patients. Published in Nature Biomedical Engineering.
- A study in Nature Chemical Biology led by CRISP-pioneer Emmanuelle Charpentier narrows CRISRP-Cas9 precision down to two groups of arginines in the Cas9 endonuclease.
- Symptoms in ALS Mouse Model Improve with CRISPR Base Editing according to a study in Molecular Therapy.
Reviews
- Recent review on multiplexing CRISPR technologies for gene editing
Industry
Avectas just raised $20 million to accelerate its novel non-viral delivery platform for gene modified cell therapy products.
Cellectis' new patent widen it's TALEN-based technology for developing universal CAR-T cells for immunotherapies to CRISPR-Cas9-based tech.
Evotec Makes Move into Gene Therapy with Takeda Deal
Heh, huh, wow
- Could a rogue scientist use CRISPR to conjure another pandemic?
- Informative infographic: How to overcome the challenges of gene therapy manufacturing.
CRISPR gene editing spotlight by the "congressional watchdog," GAO (The U.S. Government Accountability Office).
Tags
CLINICAL TRIALS
IND Enabling
Phase I
Phase II
Phase III
Recurrent or Progressive High-grade Glioma, (NCT06737146)
Sponsors:
Suzhou Maximum Bio-tech Co., Ltd.
Sponsors:
Suzhou Maximum Bio-tech Co., Ltd.
IND Enabling
Phase I
Phase II
Phase III
Advanced Peritoneal Malignancies or Abdominal Metastatic Solid Tumors, (NCT06912152)
Sponsors:
Zhejiang University
Sponsors:
Zhejiang University
IND Enabling
Phase I
Phase II
Phase III