Your missing links are here (23 October 2020)

Some of the best stuff we picked up around the internet

By: Karen O'Hanlon Cohrt - Oct. 23, 2020

Top Picks

Research

  • Researchers from Germany and the US develop compact Cascade–Cas3 system for targeted genome engineering. The system that can make larger genomic deletions than is possible with CRISPR-Cas9, with applications in research and potential for gene insertion and replacement strategies within agriculture and therapy.
  • US research team use in vivo delivery of an adenine base editor and a single guide RNA targeting a single mutation to restore sight in adult mice with the inherited retinal disease retinitis pigmentosa. Research findings published in Nature Biomedical Engineering.
  • US and Australian researchers use CRISPR to validate genetic targets that may be used in control strategies against Culex moquitoes, a globally widespread vector of human and animal pathogens. Research findings shared on preprint server bioRxiv.
  • Computer scientists at University of Oxford report crisprSQL, a novel database platform for CRISPR/Cas off-target cleavage assays. The free resource, found here, is an interactive and bioinformatically enhanced collection of CRISPR/Cas9 off-target cleavage studies that aims to support the fields of cleavage profiling, gene editing safety analysis and transcriptomics. Read the research article here.

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Heh, huh wow

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