Certainty After CRISPR

What you will learn from this webinar

• Discover potential unintended modifications during and after CRISPR/Cas9-induced edits
• See how targeted long-read sequencing can reveal otherwise undetected genome alterations
• Gain insights about different methods to validate the accuracy and precision of small and large genome edits
• Get an overview of the advantages and disadvantages of the different validation methods

Recent developments in gene-editing technologies have enabled researchers to delete, insert and change regions in genomes down to the single base level. These developments show great potential in gene editing-based next generation gene therapies. However, the primary outcome after nuclease-based gene editing is insertions and deletions (InDels) at the targeted locus in the genome. Importantly, recent observations have shown that in addition to the formation of InDels at the desired site, unexpected outcomes also occur after gene editing. Join Keyi Geng and Eric Paul Bennett in this two-part webinar discussing the nature of these unexpected gene editing outcomes and ways to detect and characterise both the expected and unexpected editing outcomes.

On-demand Access here.