Cas9

CRISPR-StAR, a novel screening technique, addresses the challenges of genetic screening in complex in vivo models by using internally controlled...

Highlight: CRISPR-Edited RUNX1 Variants Enhance...

CMN Briefs

Dec. 9, 2024

Researchers have investigated the impact of genome-edited RUNX1 loci on bone formation, revealing the regulatory influence of non-coding GWAS variants...

In Vivo T-Cell Editing in Lymph Nodes Effectively...

CMN Briefs

Nov. 26, 2024

A new method for directly editing T-cells in lymph nodes using CRISPR-Cas9 aims to enhance immune checkpoint blockade (ICB) cancer therapies. The...

In Vivo T-Cell Editing in Lymph Nodes Effectively...

CMN Briefs

Nov. 26, 2024

A new method for directly editing T-cells in lymph nodes using CRISPR-Cas9 aims to enhance immune checkpoint blockade (ICB) cancer therapies. The...

Highlight: DNA Breaks Facilitate Transfer of mtDNA...

CMN Briefs

Nov. 4, 2024

CRISPR gene editing can lead to integration of mitochondrial DNA (mtDNA) fragments into the nuclear genome, raising potential safety concerns in...

Highlight: In Utero Nanoparticle Delivery Enables...

CMN Briefs

Oct. 28, 2024

Delivering mRNA via acid-degradable nanoparticles offers a new frontier in prenatal gene editing, setting the stage for treatments targeting the root...

Highlight: CRISPR reduces the cause of blindness...

CMN Briefs

Oct. 7, 2024

In a move to potentially treat blindness, researchers have used CRISPR-Cas9 technology to permanently disrupt VEGFA expression in the eyes of rhesus...

Droplet cell mechanoporation boosts CRISPR...

CMN Briefs

Sep. 16, 2024

Researchers in South Korea have introduced a novel microfluidic platform, termed Droplet Cell Pincher (DCP), to enhance CRISPR-Cas9 genome editing....