CRISPR interference (CRISPRi) emerges as a promising approach for re-sensitising multidrug-resistant bacteria to antibiotics while avoiding mutations...
Researchers at the University of California San Diego have developed the SCHEMATIC resource, a systematic approach leveraging combinatorial CRISPR...
A new method for directly editing T-cells in lymph nodes using CRISPR-Cas9 aims to enhance immune checkpoint blockade (ICB) cancer therapies. The...
American researchers have used transcriptome-wide CRISPR-Cas13 screens in multiple human cell lines to identify 46 universally essential and more than...
Researchers have demonstrated the efficacy of a compact, specific and AAV-compatible CRISPR-Cas13 variant, Cas13bt3, for RNA-targeted gene therapy...
Researchers in Iran and Germany have developed a deep-learning model, DTMP-Prime, to improve predictions for Prime Editing (PE) efficiency and pegRNA...
Researchers in Italy and Australia report a triple combination strategy involving CRISPR that boosts the response of neuroblastoma to immunotherapy.
Jennifer Doudna and colleagues have engineered a thermostable Cas9 variant, iGeoCas9, which dramatically enhances genome editing efficiency in...
