Non-viral circular single-stranded DNA improves gene insertion efficiency and cell viability in human T-cells and haematopoietic stem and progenitor...
Feng Zhang and colleagues report that the engineering of a compact RNA-guided nuclease, NovaIscB, derived from the OMEGA system enables efficient and...
A new study using CRISPR activation in a cortical organoid model offers promise for treating a rare genetic epileptic disorder. The novel approach –...
TXNIP, a key regulator of oxidative and endoplasmic reticulum (ER) stress with established roles in diabetes, cardiovascular disease, cancer, and...
Researchers have identified a secreted protein that acts as a crucial brake on skin stem cell proliferation, offering new insights into maintaining...
Differentiated sensory neurons from human iPSCs carrying the SCN9A A1632G mutation display electrophysiological changes not seen in overexpression...
A new CRISPR-based method has been developed to functionally validate hits from pooled knockout screens by measuring shifts in indel profiles that...
A new strategy enables precise spatial and temporal control of CRISPR gene editing using chemically modified, photo-responsive guide RNAs. This...
