Genome-wide CRISPR screens in isogenic cell lines have identified synthetic lethal targets across 15 frequently altered cancer drivers, offering new...
Researchers have identified how the bacteriophage protein AcrIIA27 inhibits diverse Cas9 enzymes by binding solvent-exposed regions of the guide RNA...
A new sensitive method detects large-scale chromosomal rearrangements caused by CRISPR-Cas9 genome editing in primary human cells. The approach...
Researchers in Japan have developed CRISPR-Cas3 genome editing to target the TTR gene in transthyretin amyloidosis, achieving substantial protein...
Structural analysis of Cas5 from Moraxella bovoculi reveals that this protein functions equally well as a monomer or a dimer for RNA processing, but...
Japanese researchers have developed a screening system using diphtheria toxin resistance to identify CRISPR-Cas9 variants with enhanced...
Researchers have identified FZD6 as a promising therapeutic target for advanced prostate cancer through systematic screening of Wnt receptors,...
Neurons show slow and distinct DNA repair responses after CRISPR editing, challenging assumptions based on dividing cells. Researchers demonstrate...
