A plasmid-delivered prime editing strategy corrected the glucose-6-phosphate dehydrogenase (G6PD) Viangchan (c.871G>A) mutation in engineered HEK293T...
CRISPR-Cas12b technology was used to edit allogeneic donor islet cells for transplantation into a man with long-standing type 1 diabetes....
Building on prior work demonstrating HIV-1 elimination using dual CRISPR-Cas9 editing and antiretroviral therapy in humanised mice, this study by...
CRISPR cytosine base editors have been refined through directed evolution of enzyme recognition loops to enable highly precise DNA editing with...
A comprehensive CRISPR-CAS whole-genome screen has revealed key proteins controlling anti-sense oligonucleotide (ASO) activity, with a particular...
A tamoxifen-inducible CRISPRa/i system has been developed to enable reversible and rapid control of gene expression in mammalian cells. The platform...
A high-throughput prime editing screen in human cells reveals that some synonymous mutations, long considered functionally neutral, can significantly...
Chinese researchers have developed a thermosensitive, polyamine-modified hydrogel that significantly improves the co-delivery of CRISPR/Cas9 gene...
