A Danish team has used prime editing to repair a disease-causing GATA2 deletion in patient-derived blood stem and progenitor cells without making a...
A mutation-agnostic CRISPR-Cas strategy that inserts a functional rhodopsin coding sequence into the human RHO locus has preserved retinal structure,...
Base editing offers far more versatility than its name implies. The technique was initially developed to correct single-nucleotide variants by...
An new end-to-end nomination workflow improves the nomination of genomic sites that may be unintentionally edited by CRISPR-Cas, combining high...
Three boys with Duchenne muscular dystrophy retained broadly stable motor function one year after receiving GEN6050X, an experimental base-editing and...
Researchers at Ghent University have engineered virus-like particles decorated with anti-CD4 nanobodies to deliver CRISPR-Cas machinery selectively...
The first approved CRISPR medicine has now shown similarly strong results in children as young as five years old with sickle cell disease and...
A new CRISPR-based strategy turns cancer cells' own mutant transcripts against them, opening a potential route to one of oncology's most stubborn...
