A comprehensive CRISPR-CAS whole-genome screen has revealed key proteins controlling anti-sense oligonucleotide (ASO) activity, with a particular...
A high-throughput prime editing screen in human cells reveals that some synonymous mutations, long considered functionally neutral, can significantly...
Researchers have identified a secreted protein that acts as a crucial brake on skin stem cell proliferation, offering new insights into maintaining...
A new CRISPR-based method has been developed to functionally validate hits from pooled knockout screens by measuring shifts in indel profiles that...
Researchers have identified ARL11 as a critical factor in resistance to PARP inhibitor therapy through a genome-wide CRISPR activation screen,...
A genome-wide CRISPR screen in fibroblasts from patients with Néstor-Guillermo Progeria Syndrome (NGPS) identified 43 genes that mitigate multiple...
Researchers at ETH Zürich have introduced a combined base and prime editing approach to explore the mutational landscape of the epithelial growth...
American researchers have used transcriptome-wide CRISPR-Cas13 screens in multiple human cell lines to identify 46 universally essential and more than...
