A tamoxifen-inducible CRISPRa/i system has been developed to enable reversible and rapid control of gene expression in mammalian cells. The platform...
Researchers have identified ARL11 as a critical factor in resistance to PARP inhibitor therapy through a genome-wide CRISPR activation screen,...
Scientists have developed a method that allows for simultaneous activation, repression, and knockout of genes within a single cell. By leveraging...
A new method combines multiplexed CRISPR-based gene activation (CRISPRa) with single-cell RNA sequencing (sc-RNA-seq) to identify cis-regulatory...
Researchers have engineered a minimal type I-F2 CRISPR-Cas system capable of transcriptional activation and base editing in human cells. This...
Korean researchers have developed programmable conditional guide RNAs for precise control of endogenous gene expression using the CRISPR-Cas system....
An engineered Cas12a variant offers high-efficiency activation and repression of multiple genes in a single experiment, with applications in cellular...
In 2022, we celebrate a decade of CRISPR as a game-changing tool in research and medicine. The last 10 years have been phenomenal, and CRISPR cures...
