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CRISPR cytosine base editors have been refined through directed evolution of enzyme recognition loops to enable highly precise DNA editing with...
A comprehensive CRISPR-CAS whole-genome screen has revealed key proteins controlling anti-sense oligonucleotide (ASO) activity, with a particular...
A tamoxifen-inducible CRISPRa/i system has been developed to enable reversible and rapid control of gene expression in mammalian cells. The platform...
A high-throughput prime editing screen in human cells reveals that some synonymous mutations, long considered functionally neutral, can significantly...