Clinical Trial

Disease: Relapsed/Refractory B-cell Non-Hodgkin Lymphoma, NHL, (NCT04637763)

Disease info:

B cell lymphoma refers to types of non-Hodgkin lymphoma that are characterised by abnormalities of the "B cells" (a type of white blood cell that makes antibodies to help fight infection). B cell lymphoma may grow and spread slowly with few symptoms (also known as indolent lymphoma) or may be very aggressive with severe symptoms.

Non-Hodgkin lymphoma (also known as non-Hodgkin’s lymphoma, NHL, or sometimes just lymphoma) is a cancer that starts in a type of white blood cells called lymphocytes, which are part of the body’s immune system. NHL is a term that's used for many different types of lymphoma that all share some of the same characteristics. NHL usually starts in lymph nodes or other lymph tissue, but it can sometimes affect the skin. 

Non-Hodgkin lymphoma (NHL) is one of the most common cancers in the United States, accounting for about 4% of all cancers. About 77,240 people (42,380 males and 34,860 females) will be diagnosed with NHL. This includes both adults and children.
Official title:
A Phase 1, Multicenter, Open-Label Study of CB-010, a CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy in Patients With Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)

Socorro Portella, MD, at Caribou Biosciences Inc. ( 




United States, Arizona

United States, California

United States, Ohio

United States, Texas


United States, New Jersey

United States, Utah

Study start:
Dec. 16, 2020
50 participants
Gene editing method:
Type of edit:
Gene knock-out, gene knock-in
CD19 Molecule, Programmed Cell Death 1 (PD1), T Cell Receptor (TCR)
Delivery method:
- Ex-vivo
IND Enabling Pre-clinical
Phase I Safety
Phase II Safety and Dosing
Phase III Safety and Efficacy

Status: Active recruiting


CB-010 is manufactured from healthy donor T cells using Caribou’s next-generation CRISPR genome-editing technology. Through genome editing, PD-1 is deleted from the CAR-T cells, which in pre-clinical studies promoted an increase in the durability of antitumour activity. Genome editing is used to remove the endogenous T cell receptor in order to prevent graft-versus-host disease and to site-specifically insert the CAR into the CAR-T genome.

CB010A is a study evaluating safety, emerging efficacy, pharmacokinetics and immunogenicity of CB-010 in adults with relapsed/refractory B cell non-Hodgkin lymphoma after lymphodepletion consisting of cyclophosphamide and fludarabine.


  • Genetic: CB-010

    CB-010 is a CRISPR-edited allogeneic CAR-T cell therapy targeting CD19.

  • Drug: Cyclophosphamide

    Chemotherapy for lymphodepletion

  • Drug: Fludarabine

    Chemotherapy for lymphodepletion

Last updated: Jan. 1, 2023
Source: US National Institutes of Health (NIH)
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