Metastatic epithelial-derived solid tumours is an umbrella term that that includes tumour types such as gastric cancer, pancreatic cancer, breast cancer, ovarian cancer and many others.
Company
Metastatic epithelial-derived solid tumours is an umbrella term that that includes tumour types such as gastric cancer, pancreatic cancer, breast cancer, ovarian cancer and many others.
Contact
Name: Angie Schinkel
Phone: 858-779-3103
Email: clinicaltrials@poseida.com
United States, Colorado
Sarah Cannon Research Institute at HealthONE, Denver, Colorado, United States, 80218
United States, California
University of California, San Diego, San Diego, California, United States, 92037
University of California, San Francisco, San Francisco, California, United States, 94143
United States, Kansas
University of Kansas Cancer Center, Westwood, Kansas, United States, 66205
United States, Texas
MD Anderson Cancer Center, Houston, Texas, United States, 77030
NEXT Oncology, San Antonio, Texas, United States, 78229
Status: Active recruiting
Description
This is an open label, multi-center Phase 1 study that will follow a 3 + 3 design of dose-escalating cohorts of single and multiple doses of P-MUC1C-ALLO1 to determine a Recommended Phase 2 Dose (RP2D). P-MUC1C-ALLO1 is an allogeneic chimeric antigen receptor (CAR)-T cell therapy designed to target cancer cells expressing Mucin1 cell surface associated C-Terminal (MUC1-C) antigen. Additional participants will be treated with P-MUC1C-ALLO1 at the determined RP2D.
Following enrollment, subjects will be treated with P-MUC1C-ALLO1 and will undergo serial measurements of safety, tolerability and response.
Last updated: Jun. 5, 2023