CMN DB 2.0 - Global CRISPR Clinical Trials Database

About CRISPR Medicine News Global Clinical Trials Database 2.0

The CRISPR Medicine News (CMN) Global Clinical Trials Database 2.0 is manually curated by the CMN Intelligence team and managed by Karen O’Hanlon Court, PhD, Data Intelligence and Infrastructure Management Manager at CMN.

It aims to be the most comprehensive, up-to-date global database of clinical trials involving gene-editing technologies. This includes trials in which gene editing is used to create a therapy (e.g., ex vivo gene-edited cell therapies) as well as trials in which gene editing reagents themselves are administered as the therapeutic (e.g., in vivo gene editing therapies). Every effort is made to include all relevant trials worldwide.

Using the Database

Select the filters of interest to view results in a tabular format. Results update dynamically as filters are selected or removed.

Long-Term Follow-Up (LTFU) Studies

LTFU studies are non-interventional and do not involve administration of a therapeutic. They follow patients who have previously received a gene-editing therapy or gene-edited therapy in another trial(s).

Clinical Data and Data Sources

Where publicly disclosed, clinical data are included under Press Releases, Publications, Clinical Data. This section may contain press releases, news articles, publications (peer-reviewed and non-peer-reviewed), and patents. While we aim to provide trial-specific clinical data, some entries may include candidate-level data from multiple trials.

Information on delivery, target gene, therapeutic candidate and gene-editing modality is compiled from patents, publications, company slide decks and websites, public disclosures, news sources, and occasional communications with sponsors. Some fields may be incomplete due to limited public disclosure.

Database Access for Patients and Clinicians

This database is available with open access (free) and full access (paid) levels, which provide different sets of filters and functionality. This approach is designed to support sustainability while ensuring that patients, patient advocates and clinicians can access relevant clinical trial information.

If you are a patient, patient advocate, healthcare professional, or otherwise seeking access to information beyond what is currently available, please contact us here and we will do our best to assist you.

If you are interested in full access license options and monthly reports, please request more details here.

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