Senior Genetic Engineering Scientist



Job type

Full time


Are you looking to join a rapidly growing genetic engineering company that is generating revenue? ExpressCells speeds drug discovery and biological research by producing genetically-edited cell lines for biological researchers. We are looking for a team-oriented, enthusiastic bench scientist with microbiology and cell culture experience. Our innovative process, using CRISPR plus our patented FAST-HDR plasmid system, creates custom knock-in cell lines more quickly than current technology and allows multiple knock-ins into the same cell line. We also create cell lines that overexpress proteins or have point mutations. Most of our work is for commercial customers, but there may be opportunities to work on developmental projects. We are moving into a larger production facility in April 2022 and are seeking a team member to help us grow.

Position Description
This role’s primary responsibility is to produce genetically-edited cell lines. This employee is an accomplished scientist with experience in all steps of gene editing and mammalian cell culturing. This employee will be able to build plasmids, use CRISPR to cut into a cell’s genome, transfect and culture cells, confirm the results of the transfection process, and ensure a homogeneous cell line. This person will have the skills to operate independently in a shared laboratory space. While most of this employee’s time will be spent on production for commercial customers, there may be opportunities to work on developmental projects. This employee may also manage standard lab functions, which include documentation, ordering supplies, and shipping products.

Key Functions
Design and use of CRISPR
Molecular biology, including bacterial culturing, plasmid extraction, PCR, and gene cloning
Mammalian cell culturing
Fluorescence Microscopy
Perform QA
Communicate project updates to customers and ExpressCells leadership
Lab operations (Project documentation, ordering supplies, shipping products)

Required Knowledge, Skills, and Experience
Master’s or Doctorate in a biological field
5+ years experience (Master’s degree) or 2+ years experience (Doctorate) in gene editing, CRISPR, Gibson assembly cloning techniques, and cell culturing
Focused on details and ability to trouble-shoot laboratory issues
Fluent in speaking and writing English
Applicant must be authorized to work in the United States

Preferred Additional Credentials
Trained to use DNA analysis software (e.g,, SnapGene, Benchling)
Familiarity with iPSC cell culturing
Experience with bacterial gene cloning, Western blotting, and immunofluorescence assays 

Position Details
Reports to Scientific Director
Compensation includes competitive salary and employee stock option plan
Benefit package includes medical (ExpressCells pays 100% of premium), dental, and vision plans
Location: 3675 Market St., Philadelphia, PA. Location’s amenities include kitchens with free hot & cold beverages, fruit, snacks, and breakfast cereals; weekly Venture Café events that include speakers, networking, and free beer & wine; other events, including happy hours and food events; convenient to public transportation (subway/El, bus, SEPTA Regional Rail, Amtrak)
Travel: 0-5% of work time
Relocation: not offered

Please provide the following when applying:
Cover Letter
Up-to-date resume
LinkedIn profile URL
Earliest start date

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