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CARBON Newsletter (8 March 2022) - Your Latest News About CRISPR in AgroBio

Some of the best links we picked up around the internet

By: Gorm Palmgren - Mar. 8, 2022

CRISPR AgroBio News (CARBON) is a new initiative from CRISPR Medicine News. CARBON will bring you the latest news on how CRISPR can shape agriculture for the future to guarantee food security in times of population growth and climate change.

To get more CRISPR AgroBio News delivered to your inbox, sign up to the free weekly CARBON Newsletter here.

Top picks

  • Chinese researchers have used CRISPR-Cas9 to disrupt natural miRNA-mediated inhibition of the growth-regulating gene GS2 and thereby obtain rice with increased grain size and yield. Gene-editing resulted in a mutant named GS2E carrying an in-frame 6-bp deletion and 1-bp substitution within the miR396-targeted sequence. As a result, thousand grain weight and grain yield per plant of GS2E plants were increased by 23.5% and 10.4%, respectively.
  • When working with plants, researchers tend to pay less attention to off-target editing and other unintended gene-editing events when working with plants than in human biomedical research. An extensive literature review by Dutch researchers gathers information on the occurrence and nature of CRISPR-Cas off-target edits in plants. It is shown that off-target edits are predominantly detected via biased analysis of predicted off-target sites instead of unbiased genome-wide analysis. Furthermore, the review finds that CRISPR-Cas-edited plants showed lower off-target mutation frequencies than conventionally bred plants. This can aid discussions on the relevance of evaluating off-target modifications for risk assessment of CRISPR-Cas-edited plants.

Technical advances

Disease control

Agronomic traits

Regulation & Opinion

Reviews

Meetings

  • The 9th Plant Genomics and Gene Editing Congress: Europe will be held in The Hague, Netherlands, 11-12 April 2022. The conference will examine the latest in genomics and gene editing methods for specific crop plants and horticulture and explore developments in genomics and gene editing for plant research in crop trait development, disease resistance, epigenetics and plant breeding. Featured speakers include Beat Keller, Alan Schulman, Jurriaan Ton and Sadiye Hayta.

 

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News: CARBON Newsletter (8 March 2022) - Your Latest News About CRISPR in AgroBio
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