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CMN Weekly (6 May 2022) - Your Weekly CRISPR Medicine News

Some of the best links we picked up around the internet

By: Gorm Palmgren - May. 6, 2022

Top picks

  • American researchers have used targeted epigenomic editing to ameliorate excessive drinking in a rat model of adolescent alcohol exposure. Alcohol induces epigenetic reprogramming at the enhancer region of the activity-regulated cytoskeleton-associated protein (Arc) immediate-early gene, known as synaptic activity response element (SARE). It decreases Arc expression in the amygdala of both rodents and humans. The authors show that dCas9 fused to the histone acetyltransferase P300 increases histone acetylation at the Arc SARE and normalises deficits in Arc expression, leading to attenuation of adult anxiety and excessive alcohol drinking.

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News: CMN Weekly (6 May 2022) - Your Weekly CRISPR Medicine News
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