In vivo CRISPR gene editing in memory CD8 T cells have been achieved for the first time by temporarily inhibiting the transcription factor p53 that otherwise precludes Cas9-mediated gene disruption in this cell type.
Research
Cancer researchers in Germany have received ERC funding for single-cell CRISPR studies to unravel the biological effects of DNA circularisation and reintegration in an attempt to understand the role of extrachromosomal DNA in cancer development. See press release from Charité - Universitätsmedizin Berlin.
Efficient animal breeding often requires a surplus of a single sex. This has been achieved in a mouse model where CRISPR is used to generate all-male litters by creating a synthetic female-lethal bicomponent system.
Another global CRISPR market report from Kenneth Research takes a more research-oriented approach by breaking up the business opportunities into specific applications like genome editing, genetic engineering, gene library, CRISPR plasmid, human stem cells, genetically modified organism, and cell line engineering.
A previous panel discussion at CRISPRcon 2020 addressed how journalists are shaping society’s values and views on gene editing through their choices of what stories to tell, and how to frame them. Watch it on YouTube here.