Dual CAR-T cells incorporating an IF/THEN logic-gated system show enhanced anti-tumour cytotoxicity and reduced off-tumour effects in mouse models....

Using CRISPR-Cas9 to knock out CD5, researchers have significantly improved the efficacy of adoptive T-cell therapies for both haematological and...

Based on an evolved bacterial adenosine deaminase, DECOR represents a significant advancement in RNA editing technology by providing a more precise,...

In this brief update, we bring you the latest news from three gene-editing clinical trials sponsored by Cellectis, Intellia Therapeutics and Caribou...

Using a genome-wide in vivo CRISPR screen, a team at McGill University Health Centre in Canada identify transforming growth factor beta-3 (TGFβ3) as...

Caribou Biosciences expands its clinical programme for CB-010 with FDA nod to initiate clinical trial in lupus, Verve Therapeutics pauses ongoing...

Researchers in Germany report that CRISPR-Cas9-mediated knockout of the tyrosine kinase MerTK reduces cancer cell proliferation and migration in vitro...

In this update, we highlight recent news on Poseida Therapeutics' fully allogeneic CAR-T candidate for multiple myeloma (P-BCMA-ALLO1), Intellia's and...