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CMN Weekly (22 April 2022) - Your Weekly CRISPR Medicine News

Some of the best links we picked up around the internet

By: Gorm Palmgren - Apr. 22, 2022

Top picks

  • Novel nanocapsules containing CRISPR reagents can penetrate the blood-brain barrier and lead to high gene-editing efficiency up to 38.1% with negligible (less than 0.5%) off-target editing in a glioblastoma brain tumour in mice. In addition, treatment with nanocapsules corrected a mutation in the PLK1 gene and extended the median survival time to 68 days versus 24 days in mock-treated animals. The nanocapsules are made of a glutathione-sensitive polymer shell incorporating a dual-action ligand that facilitates BBB penetration, tumour cell targeting, and Cas9/sgRNA selective release.
  • Researchers in China have developed an upgraded prime editing platform (xrPE) with substantially enhanced editing efficiencies in multiple cell lines. The enhancement relies on appending a viral exoribonuclease-resistant RNA motif (xrRNA) to the 3'-extended portion of pegRNAs for their increased resistance against degradation Pan-target average enhancements of up to 3.1-, 4.5- and 2.5-fold in given cell types is observed for base conversions, small deletions, and small insertions, respectively.

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News: CMN Weekly (22 April 2022) - Your Weekly CRISPR Medicine News
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