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Overview: Diseases That CRISPR Potentially Could Cure

In this post, we introduce our CMN disease overview, which will provide information on all the diseases that are targeted by gene-editing therapies involving CRISPR, prime editors, base editors, ZFNs, TALENs, Cas-CLOVER, MegaTAL and MegaNucleases.

By: Karen O'Hanlon Cohrt - Feb. 24, 2022

There are now more than 100 ongoing gene-editing trials for new therapies and diagnostics, and the majority of these are evaluating CRISPR-based therapies for a growing range of diseases, including infectious diseases, blood disorders, blood and solid cancers, eye diseases, metabolic disorders, and a number of rare genetic conditions. You can view the full list of ongoing clinical trials here.

At CMN, we strive to cover all clinical and industrial news concerning therapeutic gene editing, as well as research and technological advances that solve major challenges and push gene-editing modalities towards new therapies, in many cases for incurable diseases that have limited treatment options.

CMN Disease Overview

To supplement our clinical trials listing, our weekly CMN interviews and clinical news updates, we recently began building an overview of all of the diseases that are in scope for gene-editing therapy or diagnostics.

This includes diseases that are currently being targeted in gene-editing clinical trials, as well as diseases that are being investigated at research level. Each record contains the standard disease code (ICD, according to the International Classification of Diseases), general disease description, as well as information about mutations involved (when known), disease frequency, symptoms, treatment and a list of sources used. An excerpt from our cystic fibrosis disease record is shown below.

Example of disease record for cystic fibrosis. ICD = International Classification of Diseases.
Example of disease record for cystic fibrosis. ICD = International Classification of Diseases.

All interviews and news articles related to each disease appear below each disease record. You will find the disease overview here.

CRISPR Medicine News follows all the clinical trials for gene-editing therapies. You will find a complete overview of current gene-editing clinical therapeutic trials as well as diagnostic trials, check out CRISPR Medicine News' Clinical Trials Database.

To get more of the CRISPR Medicine News delivered to your inbox, sign up to the free weekly CMN Newsletter here.

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News: Overview: Diseases That CRISPR Potentially Could Cure
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CLINICAL TRIALS
Solid tumors, (NCT05361174)
Sponsors:
Iovance Biotherapeutics, Inc.
IndicatorIndicator
IND Enabling
Phase I
Phase II
Phase III
Indicator
IND Enabling
Phase I
Phase II
Phase III
Sickle Cell Disease, SCD, (NCT05329649)
Sponsors:
Vertex Pharmaceuticals Incorporated
Indicator
IND Enabling
Phase I
Phase II
Phase III
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