Non-viral circular single-stranded DNA improves gene insertion efficiency and cell viability in human T-cells and haematopoietic stem and progenitor...

CRISPR gene editing can lead to integration of mitochondrial DNA (mtDNA) fragments into the nuclear genome, raising potential safety concerns in...

Dual CAR-T cells incorporating an IF/THEN logic-gated system show enhanced anti-tumour cytotoxicity and reduced off-tumour effects in mouse models....

In this brief update, we bring you the latest news from three gene-editing clinical trials sponsored by Cellectis, Intellia Therapeutics and Caribou...

In this clinical update, we look at recent advances in two clinical-stage gene-editing programmes. Editas Medicine's sickle cell disease candidate...

This week’s update looks at a Phase 1/2 study for ALLO-501A, a TALEN-edited CAR T-cell therapy for large B-cell lymphoma.

In recent years, researchers have turned to gene editing to address the limitations of CAR T therapies. This roundup summarises the clinical-stage...

Last week, Allogene Therapeutics announced the publication of data from the Phase 1 UNIVERSAL trial of ALLO-715, a TALEN-engineered CAR-T candidate...