A novel engineered TadA ortholog-derived cytosine base editor (aTdCBE) can overcome existing limitations in motif preferences and adenosine activity...

Researchers in France report the correction of three duplications in the dystrophin gene in cells from Duchenne muscular dystrophy patients, using...

HuidaGene Therapeutics recently announced that the FDA has granted Orphan Drug Designation to its CRISPR-based therapeutic candidate, HG302. The...

Folding DNA into compact structures allows for efficient integration of large genes, and this might lead to new therapies for genetic diseases with...

2021 was a very successful year for CRISPR in the medical field. Much of the success comes down to gene editing without double-strand breaks,...

In 2021, we've seen positive clinical data for the first ever in vivo CRISPR medicines, base editors are heading for the clinic, and CRISPR therapies...

Mammoth Biosciences was until recently most well known as a diagnostic company using CRISPR technology, but through a newly announced partnership with...

Contraction kinetics of isogenic myofibers before and after CRISPR correction are compared in a microdevice with a light pulse. The optogenetic model...